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Linwei Ran on Muck Rack

Linwei Ran

As seen in: Frontiers
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Articles

Repurposed metformin–apigenin combination therapy for metabolic dysfunction-associated steatohepatitis: from integrative multi-omics discovery to in vivo validation

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By Kanglong Zhang, Yihua Chen, Lu Dai, Zhen Yang, Qi Chen, Jie Zheng, Guoxin Hu, Linwei Ran, Weizhao Tong
| Frontiers
Abstract Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease. Although recent drugs have been approved, the complex pathophysiology of MASH limits monotherapy efficacy and generates considerable inter-patient heterogeneity. The purpose of this research was to identify new molecular targets and develop a rational combination therapeutic approach for MASH.
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