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Liru Yin

As seen in: BioRxiv
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Articles

High glucose levels impair the body's renal protective function during water deprivation by blunting the FXR-TonEBP axis

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By Tuo Wei, Jiebo Huang, Fang Tian, Liru Yin
| BioRxiv
Abstract Background Dehydration often leads to kidney-related complications, yet its impact on diabetic patients remains underexplored. This study aimed to investigate the effects of dehydration on diabetic nephropathy(DN) and the underlying mechanisms of injury. Methods We analyzed clinical outcomes in 81 dehydration-induced acute kidney injury patients (35 with diabetes) and validated findings in streptozotocin-induced diabetic mice subjected to intermittent water deprivation (WD).
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