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Lise Katrine Engesæter on Muck Rack

Lise Katrine Engesæter

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Articles

Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling

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By Antonio Molinaro, Peder Rustøen Braadland, Guido Carpino, Alba Carreras, Marios Nikolaidis, Katharina Beck, Ahmad Ali, Lars Bossen, Anna Frank, Annika Lundqvist, Brian Juran, Diletta Overi, Lei Geng, Henrik Mikael Reims, Ida Björk, Krzysztof Grzyb, Andreas Abildgaard, Trine Folseraas, Martin Cornillet, Laura Cristoferi, Marco Carbone, Vincenzo Cardinale, Marte L. Høivik, Adrian McCann, Per M Ueland, Mette Nåmdal Vesterhus, Tom H Karlsen, Henning Grønbæk, Eugenio Gaudio, Konstantinos N. Lazaridis, Annika Bergquist, Espen Melum, Fredrik Bäckhed, Johannes Roksund Hov, Petra Hanzely, Hólmfríður Helgadóttir, Bryan M. McCauley, Lise Katrine Engesæter, Sara K. V. Tjønnfjord
| Nature Verified
Abstract Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the bile ducts that can lead to biliary cancer and end-stage liver disease. PSC is associated with inflammatory bowel disease and an altered gut microbiota. However, the molecular mechanisms underlying gut–liver interactions in PSC remain poorly characterized. Here we show that the gut microbiota-derived metabolite imidazole propionate (ImP) is a disease driver in PSC.
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