Li‐Sen Lin

MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, China Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USAThese authors contributed equally to this work.Search for more papers by this author

Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H O into the highly toxic hydroxyl radical (.OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with .OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO is reported that has both Fenton‐like Mn2+ delivery and GSH depletion properties.