Liujie Zheng

L.Zheng, J.Zhou, H.Jin, et al. “Sesaminol Ameliorates Metabolic and Alcohol-Related Liver Injury by Activating the PPARα/Slc27a5 Axis-Driven Hepatic Fatty Acid β-Oxidation.” Molecular Nutrition & Food Research70, no. 10 (2026): e70506. https://doi.org/10.1002/mnfr.70506 Conflicts of Interest The authors declare no conflicts of interests. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.

Abstract Click to copy section linkSection link copied! Microglia are pivotal regulators of neuroimmune homeostasis in the central nervous system, and their dysregulation is linked to neurodegeneration and brain aging. Among the principal sesame-seed lignans, sesamin has demonstrated robust neuroprotective effects via antioxidant and anti-inflammatory pathways, whereas the neural actions and underlying mechanisms of sesaminol remain undefined.

1 Introduction Biological aging is a progressive degenerative process which is expected to become a major global public health challenge in the coming decades (Colchero et al. 2021; Zhang et al. 2022). It involves interconnected changes across multiple biological pathways, ultimately leading to cumulative damage in cells and tissues, functional decline of organs, increased risk of age-related diseases, and a shortened healthy lifespan (Li et al. 2024; Huang et al. 2025; Prattichizzo et al. 2024).