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Articles by Liyan Cui
A unified vision-language model for precision oncology and biomarker prediction in neuroblastoma
Abstract Neuroblastoma is a leading cause of childhood cancer mortality, presenting persistent management challenges due to its biological heterogeneity and the limited accessibility of molecular profiling in routine practice. Here we present NEVA (NEuroblastoma Vision–language AI), a multimodal foundation model designed to address these barriers.
Late-phase impact of CMV/EBV reactivation on survival after hematopoietic stem-cell transplantation: a 5-year single-center cohort study
Abstract Background: Whether simultaneous cytomegalovirus (CMV) and Epstein–Barr virus (EBV) reactivation confers additional late mortality beyond isolated CMV remains controversial. Methods: We retrospectively analyzed 202 consecutive first-ever hematopoietic stem cell transplantations performed between 2018 and 2019, using twice-weekly PCR surveillance and uniform preemptive therapy.
Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions - Communications Biology
Abstract Proteins in the plasma/serum mirror an individual’s physiology. Circulating extracellular vesicles (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep and unbiased proteomic analysis of circulating plasma/serum extracellular vesicles holds promise for discovering disease biomarkers as well as revealing disease mechanisms.
Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice
Kuan-Ju Chen*†, Jimin Zhang†, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins and David C. Cipolla Research Department of Insmed Incorporated, Bridgewater, NJ, United States Neutrophils have been implicated in initiating and perpetuating systemic lupus erythematosus and the resultant kidney damage in lupus nephritis (LN) patients, in part through an excessive release of neutrophil serine proteases (NSPs).
Frontiers | Investigating the causal relationship between ankylosing spondylitis and osteoporosis in the European population: a bidirectional Mendelian randomization study
Introduction Ankylosing spondylitis (AS) is an autoimmune disease characterized by chronic inflammation and new bone formation involving the central axis bone and sacroiliac joints, along with peripheral joint involvement and extra-articular involvement, which can ultimately result in inflammatory low back pain and spinal limitations. Approximately one-third of AS patients can be incapacitated (1, 2).
Influence of hemolysis on serum procalcitonin measured by electrochemiluminescence in an emergency room
Influence of hemolysis on serum procalcitonin measured by electrochemiluminescence in an emergency room Background: To investigate the effect of hemolysis on serum procalcitonin (PCT) detected by electrochemiluminescence (ECL) and to explore the possibility of establishment of a correction equation. Methods: Fifty-one blood samples from 17 patients were collected.
A zebrafish model of infection-associated acute kidney injury
Sepsis-associated acute kidney injury (S-AKI) independently predicts mortality among critically ill patients. The role of innate immunity in this process is unclear, and there is an unmet need for S-AKI models to delineate the pathophysiological response. Mammals and zebrafish (Danio rerio) share a conserved nephron structure and homologous innate immune systems, making the latter suitable for sepsis-associated AKI research. We introduced Edwardsiella tarda (E.tarda) to the zebrafish. Systemic E.
Influence of hemolysis on serum procalcitonin measured by electrochemiluminescence in an emergency room
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