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Jin Zhu

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Articles

A unified vision-language model for precision oncology and biomarker prediction in neuroblastoma

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By Jin Zhu, Ruizhen Hu, Qing Sun, Zhenzhen Zhao, Juan Carlos Cao, Kun Wang, Liyan Cui, Hongping Tang, Qianqian Fang, Sijin Jiang, Wenjian Zhang, Jiajun Xie, Shuo Kang, Dongyuan Xiao, Ming Xiao, Xuan Zhai, Yuntao Jia, Junyang Chen, Wei Yuan, Xiao Han, Le Lu, Junhan Zhao, Xiyue Wang, Yi Li, Jinxi Xiang, Biyue Zhu, Peiying Pan
| Nature Verified
Abstract Neuroblastoma is a leading cause of childhood cancer mortality, presenting persistent management challenges due to its biological heterogeneity and the limited accessibility of molecular profiling in routine practice. Here we present NEVA (NEuroblastoma Vision–language AI), a multimodal foundation model designed to address these barriers.
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Leveraging Vehicle-to-Home Technology for Residential Power Resilience during Climate–Induced Outages: An Agent-Based Modeling Approach

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By Francesco Rouhana, Jin Zhu, Amvrossios C. Bagtzoglou
| ascelibrary.org
Introduction The rise of transportation electrification is expanding the synergy between the power and transport sectors, creating new strategies to enhance resilience against weather-induced power outages (Loni and Asadi 2024; Thirumalai et al. 2024). In fact, extreme-weather events have become a primary driver of increasing outage frequency and severity, posing an imminent risk of prolonged disruptions to essential US household services (Candan et al. 2023).
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Mycobacterium tuberculosis IDH-PPARγ interaction suppresses GPX4 to drive macrophage ferroptosis and sustain persistent infection

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By Wenyuan Pu, XiMeng Zhang, Man Tian, Zhiyi He, Jin Zhu, Shiyu Song, Panpan Lian, Renwei Lu, Ranran Wang, Kai Lin, Chaode Gu, Junaid Wazir, Caiyun Wang, Yixuan Sun, Jing Yang, Yingwei Zhang, Huimei Chen, Enrico Petretto, Wangsen Cao, Rongrong Fan, Eckardt Treuter, Xia Zhang, Nannan Liu, Airong Yang, Xinchun Chen, Hongwei Wang, Zhiqiang Huang
| Nature Verified
Abstract Mycobacterium tuberculosis (M.tb) actively reprograms host lipid metabolism during infection; however, the underlying mechanism remains poorly understood. How M.tb manipulates macrophage lipid metabolism to induce lipid peroxidation and ferroptosis for bacterial persistence remains a fundamental question. Here, using single-cell RNA sequencing and proteomics, we show that M.tb infection substantially upregulates peroxisome proliferator-activated receptor gamma (PPARγ) in macrophages.
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