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Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain

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By Jingyi Wang, Shiling Chen, Jiarui Li, Xia Liu, Jiahui Wang, LIYANG HUANG, Xuan Wu, Yunjie Li, Yangyang Feng, Na Liu, Yingxin Tang, Lingqiang Zhu, Chuan Qin, Gaigai Li, Zhouping Tang, Luwei Nie
| Nature Verified
Abstract Intracerebral hemorrhage (ICH) leads to significant neuronal loss and glial scar formation, but the regenerative capacity of the adult brain remains limited. Although small-molecule-induced astrocyte-to-neuron (AtN) conversion has shown promise in vitro, in vivo applications—particularly under pathological conditions—are still scarce. We aimed to develop and validate a small-molecule cocktail for inducing astrocyte-to-neuron reprogramming in vivo following ICH.
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