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PGE2 regulates ferroptosis and osteogenesis of MC3T3-E1 cells via NOS2 - Scientific Reports
Abstract Prostaglandin E2 (PGE2) is a key inflammatory mediator in orthodontic tooth movement, yet its precise role in regulating osteogenesis remains unclear. This study investigated the mechanism by which PGE2 influences ferroptosis and osteogenesis in MC3T3-E1 cells, focusing on nitric oxide synthase 2 (NOS2). Bioinformatic analysis identified NOS2 as a core ferroptosis-related gene after orthodontic force loading.
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