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Liying Shan on Muck Rack

Liying Shan

As seen in: Nature
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Articles

Targeting N 1 -methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis

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By Haijian Sun, Wei Qing Wang, Chi Zhang, Tehan Zhang, Xiaoli Yang, Yanbin Feng, Liying Shan, Zheng Yang, Yan Zhang, Wenzhao Wang, Juncheng Wang, Xuben Hou, Shiqing Feng, Shenghou Liu
| Nature Verified
Abstract Osteoporosis is among the most common degenerative systemic bone diseases and is accompanied by abnormally downregulated oxidative phosphorylation (OXPHOS) in osteoblasts. While mutations in the tRNA methyltransferase (TRMT10C) gene in humans are known to cause OXPHOS dysfunction and early mortality, its role in bone homeostasis remains unknown.
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H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells - Cell Death & Disease

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By Yanting Hu, Heyang Zhou, Ke Liu, Xiangyue Meng, Xinru Guo, Yongbin Liu, Teng Zhang, Yang Zhou, Liying Shan, Futeng Hu
| Nature Verified
Abstract The transition from mitosis to meiosis is crucial for determining the germ cell fate and ensuring the successive production of gametes. However, the mechanisms underlying meiotic entry within the dynamic chromatin context still remain poorly understood. Herein, we demonstrate that H3K9me2, a key marker of heterochromatin formation, plays a pivotal role in the transition from mitosis to meiosis in female germ cells of mice.
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