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Multi-omics combined analysis of turmeric volatile oil alleviating allergic rhinitis through the JNK/MAPK-Relb/NF-κB pathway
Abstract We extracted turmeric volatile oil (TVO) from turmeric using supercritical CO₂ extraction for potential allergic rhinitis (AR) therapy. The volatile components of TVO were analyzed using gas chromatography mass spectrometry and gas chromatography-ion migration spectrometry. The pharmacological effects of TVO on ovalbumin (OVA)-induced AR in mice were evaluated through pathological markers, microbiomics, metabolomics, and proteomics.
Whey Protein Mitigates Oxidative Stress Injury and Improves Protein Synthesis in Mouse Skeletal Muscle by Regulating the SIRT1/Nrf2/HO‐1 Axis and AMPK/TSC2/mTOR/4EBP1 Pathway
1 Introduction Oxidative stress plays a key role in various stages of skeletal muscle injury (Kozakowska et al. 2015). Excessive exercise disrupts the normal redox balance in skeletal muscle, leading to oxidative stress (Kregel and Zhang 2007; Surh et al. 2008). Severe injury can also cause excessive proliferation of muscle cells, resulting in scar tissue formation that impairs muscle movement and joint function (Sakamoto 2021).
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