Liying Tu

Graphical Abstract Pathological Skin Fibrosis The artwork symbolises RNA modification crosstalk in skin fibrosis through Medusa and Perseus. Medusa's gaze symbolizing m6A methylation promotes fibrotic progression and transforms healthy skin into a rigid stone-like state. Perseus representing m1A methylation neutralizes this effect by reflecting her gaze and thereby inhibits fibrosis. This visual metaphor underscores m6A's detrimental role and m1A's protective function in fibrosis.

1 Introduction A series of cutaneous fibroproliferative diseases, including hypertrophic scar (HTS), keloid, and scleroderma, are clinically characterized by skin fibrosis.[1, 2] Skin fibrosis is a process characterized by excessive proliferation of fibroblasts and abnormal deposition of extracellular matrix (ECM) and is often accompanied by intolerable itching, contracture deformities, and functional impairments.[3] Considering its effects on physical, mental, and social health, skin...