Liying Xue
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Efficacy and safety of CD38-directed CAR-T cell therapy for multiple myeloma: a systematic review and meta-analysis
Abstract Background: Relapsed/refractory multiple myeloma (RRMM) remains a clinical challenge despite therapeutic advances. CD38-directed chimeric antigen receptor T-cell (CAR-T) therapy, especially dual-target CD38/BCMA constructs, represents an emerging immunotherapeutic strategy. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of CD38-directed CAR-T in RRMM. Methods: We systematically searched Medline, Embase, and Cochrane Library up to October 1, 2025.
Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial:
JACC Journals › JACC › Archives › Just Accepted Research Article : JACC Preprint Formats available You can view the full content in the following formats: Information & Authors Published In History Received: 24 July 2025 Revised: 11 August 2025 Accepted: 12 August 2025 Published online: 29 August 2025 Metrics & Citations How to cite this article: Mohammadnia, N, Xue, L, Vestjens, L. et al. Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial.
Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women:
Cardiovascular disease (CVD) remains a pressing global health challenge, with coronary heart disease (CHD) representing the leading cause of morbidity and mortality.1-3 Despite significant advancements in the clinical management of CHD, preventive strategies targeting modifiable risk factors to slow disease progression remain suboptimal.2-5 One emerging and increasingly recognized CVD risk factor is clonal hematopoiesis of indeterminate potential (CHIP), which is characterized by the...
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