Lizia Branco on Muck Rack

Lizia Branco

As seen in: Nature
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Articles

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids

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By Zeynep Yentür, Kseniia Sarieva, Daria Andreeva, Theresa Kagermeier, Federico S. Colombo, Florencia Diaz, Pierre Collignon, Katharina Becker, Christine Selhuber-Unkel, Simone A. Mayer, Lizia Branco, Christina Kulka, Mohamed A. Jarboui
| Nature Verified
Abstract Pharmaceutical agents, such as antiepileptic medications, can cross fetal barriers and affect the developing brain. Prenatal exposure to the antiepileptic drug valproate (VPA) is associated with an increased risk of neurodevelopmental disorders, including congenital malformations and autism spectrum disorder. In animal models and neural organoids, VPA has been shown to alter signaling pathways, such as Wnt pathway, providing insights into VPA-induced neurodevelopmental defects.
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