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Llewelyn Levett

As seen in: Nature
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Articles

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity

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By Sam O Kleeman, Kevin Michalski, Xiang Zhao, Miriam Ferrer, Austin Schultz, Noriko Simorowski, Tse-Luen Wee, Cristina Neto Valente, Sharon Fox, Mateusz Makuch, Ruby Harrison, Claire M. Regan, Jonathan B Preall, Qing Gao, Dennis Thomas, Jill Habel, Rachel Rubino, Sarosh R Irani, Hiro Furukawa, Tobias Janowitz, Ruben Steigerwald, Llewelyn Levett, Ethan Ertel, Pamela Moody, Selina Thomsen
| Nature Verified
Abstract Autoimmunity and anti-cancer immunity lie on the same biological continuum1,2, but their link remains obscure. The paraneoplastic neurological syndrome ANRE (anti-NMDA receptor (NMDAR) encephalitis) is a paradigm for their connectivity3, given that intratumoural NMDAR expression is correlated with the generation of anti-NMDAR antibodies4,5.
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