Lmi Drisa

INTRODUCTION Tuberculosis (TB) is mainly caused by Mycobacterium tuberculosis and is one of the deadliest infectious diseases worldwide, with 1.3 million deaths annually [1]. The emergence of drug-resistant TB, especially multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, strongly threatens global TB control. Globally, an estimated 10.6 million people developed TB, in which approximately 410.000 people developed MDR/rifampicin-resistant TB (RR-TB) [1].

1. Introduction The rapid increase of antibiotic-resistant bacteria, which is the consequence of excessive and inappropriate use of antibiotics (Kahlmeter et al., 2003; Costelloe et al., 2010), is a tremendous public health issue because it hinders the proper treatment of infections, thus increasing morbidity and mortality and also healthcare costs (Cosgrove and Carmeli, 2003).

Quang Huy Nguyen1, Hang T. Le1, Son T. Nguyen1, Oanh T. Nguyen1, Quyen V. Dong1, 2, Juliette Hayer3, 4, Anne-Laure Bañuls3, 4 and Tam Tran1* 1University of Science and Technology of Hanoi (USTH), Vietnam 2Institute of Biotechnology, Vietnam Academy of Science and Technology, Vietnam 3LMI DRISA, Vietnam 4Université de Montpellier, France The final, formatted version of the article will be published soon.