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Lobna Elsayed on Muck Rack

Lobna Elsayed

As seen in: BioRxiv
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Articles

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

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By Rida Rehman, Florian olde Heuvel, Albrecht Froehlich, Lobna Elsayed
| BioRxiv
Abstract Background: Traumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines. Several receptor tyrosine kinases (RTK) are activated in microglia upon TBI, and their blockade may reduce the acute inflammation and decrease the secondary loss of neurons; thus RTKs are potential therapeutic targets.
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