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Lochana M. Seenappa on Muck Rack

Lochana M. Seenappa

As seen in: Science Magazine, BioRxiv
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Articles

Lymph node–targeted DNA engages TBK1/IFN-I–driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs

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By Xiao Yu, Fan Xia, Bolan Gan, Martin P. Steinbuck, Lochana M. Seenappa, Wei Zhan, Erica Palmer, Mimi Jung Verified, Aniela Jakubowski, Xavier Cabana-Puig, Lisa Mcneil, Christopher Haqq, Katherine Fitzgerald, Peter Demuth
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Adjuvants are immunoactivators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses.
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Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates

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By Martin P. Steinbuck, Lochana M. Seenappa, Wei Zhan, Erica Palmer
| BioRxiv
Abstract Adjuvants are immuno-activators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses; the latter being indispensable for protection against intracellular pathogens and cancer.
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A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2

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By Lisa Mcneil, Martin P. Steinbuck, Lochana M. Seenappa, Aniela Jakubowski
| Science Magazine Verified
Abstract The profound consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mandate urgent development of effective vaccines. Here, we evaluated an Amphiphile (AMP) vaccine adjuvant, AMP-CpG, composed of diacyl lipid–modified CpG, admixed with the SARS-CoV-2 Spike-2 receptor binding domain protein as a candidate vaccine (ELI-005) in mice. AMP modification efficiently delivers CpG to lymph nodes, where innate and adaptive immune responses are generated.
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