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Articles by Loïc Binan
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH - Nature Reviews Genetics
Gene regulatory networks control functional phenotypes in cells and tissues. In complex tissues, these networks span cells and cell types to generate specialized functions, and are frequently dysregulated as both a cause and a consequence of disease. Technologies that leverage CRISPR–Cas9 to measure how gene silencing affects the expression level of other genes in the same cell, such as CROP-seq, Perturb-seq and CRISP-seq, are powerful tools to map intracellular genetic networks.
Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular, intercellular, and functional transcriptional circuits.
Abstract Pooled optical screens have enabled the study of cellular interactions, morphology, or dynamics at massive scale, but have not yet leveraged the power of highly-plexed single-cell resolved transcriptomic readouts to inform molecular pathways.
Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations
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Optimization-Based Decoding of Imaging Spatial Transcriptomics Data
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Pyramidal neuron subtype diversity governs microglia states in the neocortex - Nature
Abstract Microglia are specialized macrophages in the brain parenchyma that exist in multiple transcriptional states and reside within a wide range of neuronal environments1,2,3,4. However, how and where these states are generated remains poorly understood. Here, using the mouse somatosensory cortex, we demonstrate that microglia density and molecular state acquisition are determined by the local composition of pyramidal neuron classes.
GABA-receptive microglia selectively sculpt developing inhibitory circuits
(Cell 184, 4048–4063.e1–e32; July 22, 2021) It has come to our attention that, in the originally published version of our article examining how GABA-receptive microglia selectively regulate the development of inhibitory synapses in the mouse, Figure 1B had an accidental duplication of the data from the P4 samples instead of P8 (as indicated). The duplication occurred on a preliminary graph that initially contained data from all ages but was later split.
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Highlights • GABA-receptive microglia interact with inhibitory synapses during development • Removing GABABRs from microglia alters inhibitory but not excitatory connectivity • Synapse pruning genes are altered in GABA-receptive microglia lacking GABABRs • Mice lacking microglial GABAB1Rs exhibit behavioral abnormalities Summary Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring.
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