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Loise Raberg on Muck Rack

Loise Raberg

As seen in: BioRxiv
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Articles

Sialoglycans Modulate Siglec-5 - TLR4 Interactions in Osteoarthritis

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By Loise Raberg, Fan Jia, Ula von Mentzer, Vignesh Venkatakrishnan
| BioRxiv
Abstract Osteoarthritis (OA) is characterized by chronic, low-grade inflammation that contributes to cartilage degradation and joint pain. We previously identified Siglec-5 in synovial fluid of OA patients (OA SF), which prompted us to investigate its interaction with the sialylated proinflammatory receptor TLR4 in monocytes. Here, we reveal an inverse correlation between Siglec-5 and TLR4, suggesting Siglec-5 may suppress inflammation.
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Sialoglycans modulate Siglec-5 - TLR4 Interactions in Osteoarthritis

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By Fan Jia, Niclas G. Karlsson, Loise Raberg, Ula von Mentzer
| BioRxiv
Abstract Osteoarthritis (OA) is characterized by chronic, low-grade inflammation that contributes to cartilage degradation and joint pain. We previously identified Siglecs in the synovial fluid of OA patients (OA-SF), and together with studies implicating Siglecs in arthritic diseases prompted us to investigate the interplay between Siglec-5, Siglec-9, and TLR4 in monocyte regulation during OA.
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