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Lon Wolf Fong

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"Membrane Anchoring of the Diras3 N-terminal Extension Permits Tumor Su" by Xiaowen Liang, Sung Yun Jung et al.

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By Xiaowen Liang, Sung Yun Jung, Gamze Bildik, Lon Wolf Fong
| Texas Medical Center
DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This NTE and the prenylated C-terminus are required for DIRAS3-mediated inhibition of RAS/MAP signaling and PI3K activity at the plasma membrane. In this study, we applied biochemical, biophysical, and computational methods to characterize the structure and function of the NTE.
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