Long-Long Fan

Abstract Recently, the perspective of paternal origin has emerged, yet its role in motor disorders remains unclear. Here, using Drosophila and murine models, we demonstrated that following paternal environmental heavy metal stress, offspring from multiple generations exhibited progressive motor deficits accompanied by dopaminergic neuron loss.

Abstract Environmental stressors–induced male infertility has become a major public health issue. Sperm motility is the key to conception. However, the immunological mechanism for environmental stress–induced sperm motility reduction remains unknown. Our experiments find that three classical environmental stressors, including lead, cadmium, and mercury, are the key heavy metals reducing sperm motility.