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Articles by Long Yi
What The Industry Gets Wrong About Building An AI SRE
Long Yi is a co-founder of IncidentFox, building AI SRE. Before I started building AI for incident response, I was the one getting paged at 3 a.m. As a database site reliability engineer (SRE) supporting infrastructure for over 100 million daily active users, I spent too many nights root-causing production issues while simultaneously answering questions from multiple stakeholders in Slack.
Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation (Adv. Sci. 45/2025)
Graphical Abstract Regular versus Irregular Exercise Regular exercise induces septal cholinergic-hippocampus-vagus nerve circuit aiding fear memory extinction and live protection, whereas irregular exercise lacks the benefit and may cause liver inflammation. The two flying fairies symbolize “exercise,” while the sun and moon at the center represent the “regularity”.
Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation
1 Introduction Although it is widely acknowledged that exercise provides numerous benefits to the human body, the effects of exercise on the body in relation to the balance between training variables—volume, intensity, and frequency—are complex and multifaceted and involve physiological, neurological, and psychological adaptations.[1-4] Understanding how these variables interact is crucial for optimizing performance, preventing injury, and promoting long-term health.
Back Cover: Quantum Mechanical Tunnelling Probes With Redox Cycling for Ultra‐Sensitive Detection of Biomolecules
Long Yi State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027 China Nanhu Brain-Computer Interface Institute, Second Affiliated Hospital School of Medicine, Hangzhou, Zhejiang, 311100 China Department of Chemistry, Molecular Science Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 0BZ UK Search for more papers by this author
Intramolecular Thiol‐Promoted Decomposition of Cysteine Ester (ITPDC): A General Platform for Controllable Release of Reactive Sulfur Species
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Quantum Mechanical Tunnelling Probes with Redox Cycling for Ultra‐Sensitive Detection of Biomolecules
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Fast Intramolecular Thiol-Activated Arylselenoamides Provide Access to Triggered, Fluorogenic H2Se Donors
Selenium is a nutritionally essential trace element for human health, and Se deficiency is associated with many diseases. (1) All dietary Se, in both inorganic and organic forms, is metabolized by several different pathways to a shared metabolite, hydrogen selenide (H2Se, pKa = 3.9, mostly as HSe– at pH 7.4) (Figure 1a). (2) H2Se is the starting point for the downstream biosynthesis of all known Se-containing biomolecules, including proteins, nucleic acids, and small organoselenium molecules.
Dihydromyricetin promotes GLP-1 secretion to improve insulin resistance via "gut microbiota-CDCA"
Abstract Dihydromyricetin (DHM) is a polyphenolic phytochemical found mainly in plants such as Ampelopsis grossedentata, which has beneficial effects on insulin resistance. However, the specific mechanism has not been clarified. In this study, C57BL/6 mice were exposed to a high-fat diet (HFD) for eight weeks. DHM could improve insulin resistance via enhancing the incretin effect.
Largely conjugated planar acceptor and rotatable donors to construct AIEgens with large molar extinction coefficients for the detection of metal ions
Largely conjugated planar acceptor and rotatable donors to construct AIEgens with large molar extinction coefficients for the detection of metal ions Ying Zhang, Long Yi, Xiaofang Zhang, Chunbin Li, Lingxiu Liu, Jian-Ye Gong, Lina Feng, Jianguo Wang, Zhe Jiao and Guoyu Jiang Abstract To maintain high molar extinction coefficients when fabricating luminogens with aggregation-induced emission characteristics (AIEgens) is of great significance but yet challenging.
A unique reaction of diphenylcyclopropenone and 1,2-aminothiol with releasing the thiol for multiple bioconjugation
A unique reaction of diphenylcyclopropenone and 1,2-aminothiol with releasing the thiol for multiple bioconjugation Shanshan Liu, Haishun Ye, Long Yi and Zhen Xi Abstract Selective reaction of diphenylcyclopropenone (DPCP) and 1,2-aminothiol in water at pH 7.4 produces an amide conjugate with releasing the thiol. In addition, structural modifications of DPCP enable the coupling rate to be tuned with a reaction constant of +3.68.
Thiolysis of CBD arylethers for development of highly GSH-selective fluorescent probes
Thiolysis of CBD arylethers for development of highly GSH-selective fluorescent probes You have access to this article Please wait while we load your content... Something went wrong. Try again?
Hepatic PKA inhibition accelerates the lipid accumulation in liver
Abstract Background/aims Liver lipid accumulation induced by high-fat diet (HFD) is an early onset process of non-alcoholic fatty liver diseases (NAFLD). Protein kinase A (PKA) is known to be involved in hepatic lipid metabolism. However, the role of PKA in NAFLD has not been well tested in vivo due to the lack of optimal PKA deficient mouse model. Methods A novel PKA-specific inhibitor gene was conditionally overexpressed in mouse (PKAi mouse) liver using LoxP/Cre system.
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