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Abstract The advent of spatial transcriptomics has dramatically expanded our ability to study the vast network of cell-cell interactions at the molecular level in tissue. Among current methods, sequencing-based approaches have great potential in discovery because of their unbiased capture of the whole transcriptome. In the last couple of years, the spatial resolution for the capture addresses has been improved from ~100 μm to <1 μm, well below the size of a mammalian cell.
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