Longming Huang on Muck Rack

Longming Huang

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Articles

Intercellular chemerin-cmklr1 couples epicardial mechanosensing to fibroblasts in pressure overload

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By Guowei Zeng, Xinjie Zhang, Kai Luo, Xiaoyang Zhang, Bo Chen, Cong Li, Haoyu Li, Jinghao Zheng, Bozhong Shi, Xiaomin He, Longming Huang
| Nature Verified
Abstract Mechanical sensation has become a recent focus and key pathological driver of cardiac fibrosis. However, the crosstalk between major mechanosensitive cell and fibroblasts remains to be elucidated. In this study, single-cell temporal atlas of mechanosensitive ion channels is depicted in transverse aortic constriction male mouse heart. Piezo1 is the most abundant mechanosensitive ion channel and exhibits the highest expression in epicardial cells.
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