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A smart photothermal microneedle system for dual-targeted therapy of osteoarthritis via MMPs inhibition
Abstract Temporomandibular joint osteoarthritis (TMJ-OA) causes chronic pain, cartilage degeneration and pathological neurovascular remodeling, yet effective local therapies remain limited. Here we develop a minimally invasive near-infrared (NIR)-responsive microneedle system (SFZICC MNs) that integrates cryptochlorogenic acid (CCA)- and carbon quantum dot-loaded ZIF-8 nanoparticles within a methacrylated silk fibroin hydrogel.
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