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Articles by Lora Pless
Pharmacological Interventions for Weight Reduction in Patients With Schizophrenia Treated With Antipsychotics : A Systematic Review and Network Meta-Analysis
Pharmacological Interventions for Weight Reduction in Patients With Schizophrenia Treated With Antipsychotics: A Systematic Review and Network Meta-Analysis Key Points Question Which pharmacological interventions are associated with reducing body weight in individuals with schizophrenia spectrum disorders (SSDs) treated with antipsychotics?
Brain-wide mapping reveals temporal and sexually dimorphic opioid actions - Communications Biology
Abstract The field of neuroscience has been transformed by recent advances in spatial mapping of neuronal activity across whole cleared brains. Rapid adoption of these techniques requires computational workflows that can facilitate experiments comparing multiple conditions across large cohorts of individuals. We therefore developed a scalable approach for anatomical mapping of c-Fos positive cells in whole brain and applied it to map the response to the prototypic opioid, morphine.
Genomic sequencing surveillance of patients colonized with vancomycin-resistant enterococci improves detection of healthcare-associated transmission - BMC Global and Public Health
This was a retrospective observational study of VRE isolates collected from patients at UPMC Presbyterian Hospital, an adult tertiary care hospital with over 750 beds (including 134 critical care beds). During the study period, contact precautions were used for the care of any patient with a history of VRE carriage. Patients with VRE carriage were cared for in single-bedded rooms or were cohorted in double-bedded rooms only if the roommate was also known to have VRE carriage.
Psychiatric factors predict type 2 diabetes mellitus in US Veterans - Schizophrenia
Abstract Co-occurrence of type 2 diabetes mellitus (T2D) and serious mental illnesses (SMI) is prevalent yet underappreciated, and significantly contributes to increased morbidity and reduced lifespan. There is, therefore, a need to identify T2D risk factors to inform preventative approaches to the care of SMI-diagnosed patients.
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium - Nature Microbiology
Abstract Gastrointestinal colonization by the nosocomial pathogen vancomycin-resistant Enterococcus faecium (VREfm) can lead to bloodstream infections with high mortality rates. Shifts in VREfm lineages found within healthcare settings occur, but reasons underlying these changes are not understood. Here we sequenced 710 VREfm clinical isolates collected between 2017 and 2022 from a large tertiary care centre.
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