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Lorelei Ann Mucci

As seen in: Nature
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Articles

Multi ancestry genome wide association meta analysis of urinary aMT6s levels

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By Ziwei Zhang, Daniel Evans, Jesse Valliere, Matthew Maher, Jie Hu, Rebecca C. Richmond, Constance Turman, Jaime E Hart, Jacqueline M Lane, Loic Le Marchand, Lynne R Wilkens, Matthias Wielscher, Christopher A. Haiman, Iona Cheng, A. Heather Eliassen, Katie Stone, Gregory J. Tranah, Yi-Cheng Chang, Eva S Schernhammer, Richa Saxena, Gwo-Tsann Chuang, Lorelei Ann Mucci
| Nature Verified
Abstract Melatonin regulates circadian rhythms, metabolism, and immunity. Its primary metabolite, 6-sulfatoxymelatonin (aMT6s), is a biomarker linked to cancer risk and metabolic disorders. However, genetic determinants of aMT6s remain poorly understood, with only one prior GWAS limited to an East Asian cohort.
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