Lorella Maniscalco

1 Introduction Pyometra is an ascending bacterial infection that affects more than 20% middle-aged to elderly intact bitches (1, 2). The pus-filled uteri show macroscopical and histological alterations that can have different degrees of severity (3) and uterine wall rupture can occur. The microorganisms that are involved in the pathology belong to the host’s vaginal or intestinal microbiota (4), with the prevalence of Escherichia coli (E.

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Get full access to this article View all access and purchase options for this article. References 1. Abou Khouzam R, Brodaczewska K, Filipiak A, et al. Tumor hypoxia regulates immune escape/invasion: influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies. Front Immunol. 2020;11:613114. 2. Barsoum IB, Smallwood CA, Siemens DR, et al. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 2014;74:665–674. 3. Bergman PJ. Canine oral melanoma.