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NEW INSIGHTS INTO THE HEPATIC IRON PHENOTYPE OF BMP6 KNOCKOUT MICE

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By Celine BESSON, Alexandra WILLEMETZ, Chloe LATOUR, Lorenne ROBERT
| biorxiv.org
Abstract Objective: Bmp6 knockout (KO) mice progressively accumulate a significant amount of iron in their liver as they age due to a defect in hepcidin (Hamp) expression and an upregulation of the iron exporter ferroportin (Fpn). In this study, we conducted a comprehensive investigation of the hepatic iron overload phenotype, with specific emphasis on the cellular and subcellular localization of Fpn in Bmp6 KO mice.
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