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STIM1-induced widening of non-pore-lining TM interfaces is crucial for Orai1 pore opening
Keywords STIM1 Orai CRAC channel genetic code expansion photocrosslinking pore opening molecular dynamics simulations electrophysiology ion channel unnatural amino acid, UAA Introduction A wide range of cellular processes, including cell proliferation, cell motility, or secretion of inflammatory mediators is driven by store-operated Ca2+-release-activated Ca2+ (CRAC) channels.1 CRAC-channel activation is initiated by Ca2+ release from the endoplasmic reticulum (ER) and is a crucial Ca2+ entry...
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