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Lorenz Trümper

As seen in: Nature
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Articles by Lorenz Trümper

Brentuximab vedotin plus chemotherapy for the treatment of front-line systemic anaplastic large cell lymphoma: subgroup analysis of the ECHELON-2 study at 5 years’ follow-up | Blood Cancer Journal

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By Eva Domingo-Domènech, Steven Horwitz, Lorenz Trümper, Giuseppe Gritti, Pier Luigi Zinzani, Andreas Hüttmann, Marek Trneny
| Nature Verified
Abstract Trial registration: ClinicalTrials.gov number: NCT01777152 Introduction Peripheral T-cell lymphomas (PTCLs) represent ~10–15% of non-Hodgkin lymphomas [1, 2]. Systemic anaplastic large cell lymphoma (sALCL), a PTCL subtype characterized by universal CD30 expression [3, 4], is therefore a candidate for CD30-targeted treatment. sALCL is sub-divided by the presence or absence of anaplastic lymphoma kinase (ALK) protein [5].
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Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules - Leukemia

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By Anja Fischer, Helene Kretzmer, Daniel Hübschmann, Michael Hummel, Wolfram Klapper, Maciej Rosolowski, Matthias Schlesner, Stephan Stilgenbauer, Ralf Küppers, Coral del Val, Reiner Siebert, Selina Glaser, Lorenz Trümper
| Nature Verified
To the Editor: Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the most common lymphomas, both exhibiting features of germinal center-derived B-cells (gcBCs). DLBCL can arise de novo or through transformation of a low-grade lymphoma like FL. FL and DLBCL are heterogeneous with regard to clinical outcome as well as morphologic, immunophenotypic, genetic, transcriptomic and other biological aspects [1].
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