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Matthias Schlesner

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Articles

The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemia

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By Cristina Lopez Verified, Cristina Sen López, Nnamdi Okeke, Christoph Wiegreffe, Susanne Bens, Emil Chteinberg, Barbara Eichhorst, Martin Dyer, Anja Fischer, Kirsten Fischer, Selina Glaser, Michael Hallek, Helene Kretzmer, Anja Mottok, Jan P. Meier-Kolthoff, Matthias Schlesner, Christof Schneider, Stefan Britsch, Ole Ammerpohl, Stephan Stilgenbauer, Eugen Tausch, Reiner Siebert, Cosima Drewes, Billy Jebaraj, Isabelle Kraus, Sina Hillebrecht, Amani Awada, Sarah Datismann, Dominick Pfaff, Karoline Schnitzler
| Nature Verified
Abstract Activation of oncogenes by hijacking immunoglobulin gene loci (IG) enhancers via chromosomal translocation is a common pathogenetic mechanism in B-cell malignancies, affecting 5–10% of chronic lymphocytic leukemia (CLL). The oncogenic partners in many of these cases remain unidentified. Therefore, we conducted a comprehensive analysis of 144 CLL samples with IGH-translocation excluding IGH::BCL2, IGH::CCND1, IGH::BCL3 and IGH::MYC.
Open in Who Shared Issue with article?

Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor

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By Marcus Renner, Nagarajan Paramasivam, Christoph E. Heilig, Annika Schneider, Jennifer Hüllein, Barbara Hutter, Cihan Erkut, Andreas Mock, Eva I. Krieghoff-Henning, Amirhossein Sakhteman, Matthew The, Tony Prinz, Panna Lajer, Katja Beck, Bettina Beuthien-Baumann, Leonidas Apostolidis, Sebastian Bauer, Melanie Boerries, Christian H. Brandts, Damian T. Rieke, Thomas Kindler, Frederick Klauschen, Klaus Schulze-Osthoff, Richard F. Schlenk, Guy Berchem, Michael Allgäuer, Gunhild Mechtersheimer, Albrecht Stenzinger, Daniel B. Lipka, Matthias Schlesner, Bernhard Kuster, Arne Jahn, Evelin Schröck, Christoph Heining, Peter Horak, Simon Kreutzfeldt, Daniel Hübschmann, Wolfgang Hartmann, Hanno Glimm, Stefan Fröhling, Małgorzata Oleś, Caroline Modugno, Catherine Herremans, Cecilia B. Jensen, Annika Baude-Müller, Maria-Veronica Teleanu
| Nature Verified
Abstract Desmoplastic small round cell tumor (DSRCT) is an ultra-rare sarcoma with limited treatment options. Here, we show that comprehensive molecular profiling informs diagnosis and individualized therapy in this disease. We report the results of whole-genome/exome, transcriptome, and DNA methylome analyses performed in 30 refractory DSRCT patients, complemented by (phospho)proteomic profiling in nine, within a nationwide precision oncology program.
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A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification - Nature Genetics

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By Yiheng Tang, Ferdinand Zettl, Salvatore Benfatto, Martin Sill, Yahaya A. Yabo, Matthieu Peyre, Roman Sankowski, Philipp Sievers, C. Oliver Hanemann, Christian Mawrin, Olivier Ayrault, Michael Platten, Tim Kacprowski, Markus List, Jan Baumbach, Miriam Ratliff, Jan-Philipp Mallm, Eelke M Bos, Marco Prinz, Michael Weller, Felix J. Hartmann, Matthias Preusser, Christel Herold-Mende, Sandro M. Krieg, Stefan M. Pfister, Wolfgang Wick, Andreas von Deimling, Dieter Henrik Heiland, Volker Hovestadt, Moritz Gerstung, Matthias Schlesner, Christina Blume, Domenico Calafato, Helin Kardo
| Nature Verified
Abstract Classification of tumors in neuro-oncology today relies on molecular patterns (mostly DNA methylation) and their machine learning-supported interpretation. Understanding the process of algorithmic interpretation is essential for safe application in clinical routine. This is paradigmatically true for the most common primary intracranial tumor in adults, meningioma.
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