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Lorenza Bartu

As seen in: Nature, Microbiology Research
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Articles

15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial

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By Lorenza Bartu, Gina Marke, Phyu Mar, Sari Feldman, Graham J. Britton, Varun Aggarwala, Gerold Bongers, Zhihua Li, Nancy Yang, Elizabeth L. Hohmann, Ilaria Mogno, Jeremiah Faith, Ari M. Grinspan, Lukas Bethlehem, Joseph Eggers, Constantin Ruprecht
| Nature Verified
Abstract Fecal microbiota transplant (FMT) is an effective therapy for recurrent Clostridioides difficile infection (rCDI) but has undefined composition and poor scalability. In vitro manufactured live biotherapeutic products (LBPs) enable both scalability and defined strain composition but with higher manufacturing complexity, resulting in few LBP clinical trials. Here we show how an accessible platform to produce human-grade LBPs could accelerate LBP development.
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Plasmid prevalence is independent of antibiotic resistance in environmental Enterobacteriaceae

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By Suhyeon Kim, Abhishek Sharma, Danya Gewurz, Lorenza Bartu
| Microbiology Research
Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001453 Download as PowerPoint /deliver/fulltext/mgen/11/8/mgen001453.html?itemId=/content/journal/mgen/10.1099/mgen.0.001453&mimeType=html&fmt=ahah References Lopatkin AJ, Sysoeva TA, You L. Dissecting the effects of antibiotics on horizontal gene transfer: analysis suggests a critical role of selection dynamics. Bioessays 2016; 38:1283–1292 [View Article] [PubMed] [Google Scholar] Lopatkin AJ, Sysoeva TA, You L.
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