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Lorenzo Baronti on Muck Rack

Lorenzo Baronti

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Articles

Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA

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By Lorenzo Baronti, Parisa Ebrahimi, Luis Silva, Carolina Fontana
| Nature Verified
Abstract MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At present, the major parameter that can explain the selection of the target mRNA and the efficiency of translation repression is the base pairing between the ‘seed’ region of the miRNA and its counterpart mRNA1.
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