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1. Introduction Click to copy section linkSection link copied! Protein aggregation is a fundamental biophysical process, implicated in both functional and disease processes. Among the most striking─and important─classes of protein aggregates are fibrils. Fibrils are highly structured peptide aggregates consisting of repeated patterns of interactions between protein monomers and oligomers. Fibrils are implicated in a wide variety of chronic diseases, (1−3) while also having some functional roles.
Significance We examine the effects of an uneven population distribution on the spread of the COVID-19 disease spread, using a diffusion model based on interpersonal contact networks. Taking into account spatial heterogeneity, the spread of COVID-19 is much “burstier” than in standard epidemiological models, with substantial local disparities in timing and severity and long lags between local outbreaks.
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