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Highlights • Long-term outcome after isolated local recurrence (ILR) in early-breast cancer. • Data pooled from EORTC ‘boost-no boost’ (N = 5569) and IM-MS (N = 4004) trials. • In the case of ILR, 12% occurred in the first 2 years while 30% only after 10 years. • 10-year breast cancer mortality rate after ILR was higher in the case of early ILR. • Multistate model predicted outcome based on patient data, FU length, the timing of ILR.
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