Louise Randall on Muck Rack

Louise Randall

As seen in: The Sun, Wales on Sunday, Science Magazine, Birmingham Mail, Liverpool Echo, Scottish Daily Record, Coventry Live, East Riding Mail, Nottingham Post, Devon Live, Kent Live and
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Articles

Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling

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By Ye Liu, Man Dinh Nguyen, Johan A. Eckdahl, Danielle Clucas, Cavan Bennett, Rebecca Harding, Anne Pettikiriarachchi, Andrew J Baldi, Louise Randall, Ryan W.J. Steel, Melissa Hobbs, Martin Mwangi, Katherine L. Fielding, Peter Hickey, Tracey M. Baldwin, Ronan Mellin, Sabrina Caiazzo, Daniela Amann-
| Science Magazine Verified
Abstract Iron deficiency, anemia, and Plasmodium infection are global health challenges with overlapping geographical distributions, particularly affecting pregnant women in Africa, yet the mechanisms underlying their interactions remain poorly understood. We used a multilayered approach combining clinical data from Malawian pregnant women (n = 711) in the REVAMP trial, a genetic mouse model [Tmprss6-knockout (KO)], and in vitro Plasmodium falciparum cultures to clarify iron-malaria associations.
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