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Lu-Jun Yin on Muck Rack

Lu-Jun Yin

As seen in: MDPI, Taylor & Francis Online
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Articles

Repurposing GS-441524 to inhibit biofilm formation and virulence of Bacillus cereus

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By Kai-Zhong Xu, Di Meng, Lu-Jun Yin
| Taylor & Francis Online
Abstract Bacillus cereus is a resilient foodborne pathogen, with biofilm formation and virulence regulated by quorum sensing (QS). This study evaluates GS-441524, the active metabolite of remdesivir, as an anti-virulence agent against B. cereus. At sub-inhibitory concentrations, GS-441524 dose-dependently reduced protease, lipase, hemolysin, and AI-2 production, impaired motility, and inhibited biofilm formation.
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An Investigation of Quorum Sensing Inhibitors against Bacillus cereus in The Endophytic Fungus Pithomyces sacchari of the Laurencia sp.

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By Ai-Qun Jia, Shi-Liang Xiang, Kai-Zhong Xu, Lu-Jun Yin
| MDPI
1. Introduction Seaweeds, the largest group of oceanic plants, are capable of producing various metabolites, including polysaccharides, terpenes, and lectins [1]. Algal metabolites exhibit a range of beneficial effects, such as antibacterial, antiviral, antioxidant, and anticancer properties [1,2,3,4]. Endophytic fungi, residing within the plant body, coexist without harming the host and can synthesize compounds similar to those produced by the host plant [5].
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