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Articles by Lu Si
A phase II peri-operative study of pembrolizumab plus lenvatinib for mucosal melanoma
Abstract Mucosal melanoma is an aggressive malignancy with limited neoadjuvant options. We conducted a single arm, phase II study of neoadjuvant pembrolizumab plus lenvatinib followed by surgery and adjuvant pembrolizumab in resectable mucosal melanoma (NCT04622566) along with exploratory biomarker analysis.
A randomized, crossover trial of one night of oxygen therapy for obstructive sleep apnea in patients with fibrotic interstitial lung disease - Sleep and Breathing
Abstract There is no satisfactory treatment for obstructive sleep apnea (OSA) in patients with interstitial lung disease (ILD) because of poor tolerance of positive airway pressure (PAP) therapy. Supplemental oxygen therapy has been shown to reduce hypoxemia and is well tolerated in patients with ILD. However, little is known about the effect of nocturnal oxygen supplementation (NOS) on OSA in patients with ILD. In this study, we evaluated one night of oxygen therapy in ILD patients with OSA.
An Improved Orthogonal Matching Pursuit Algorithm for CS-Based Channel Estimation
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Efficient Precoding and Power Allocation Techniques for Maximizing Spectral Efficiency in Beamspace MIMO-NOMA Systems
1.1. Prior Works Typically, the optimization of precoding and power allocation designs is considered a means to improve the performance of beamspace MIMO-NOMA systems. These problems have been investigated jointly or partially. However, the presence of inter-beam and intra-beam interference makes these problems non-convex and challenging to solve [5]. Fortunately, researchers have developed efficient algorithms to tackle these challenges.
[영상] 中 전기차 브랜드, 케냐의 녹색 모빌리티 전환 도와
中 전기차 브랜드, 케냐의 녹색 모빌리티 전환 도와 (01분33초) 케냐 나이로비에서 제2차 유엔 해비타트 총회가 열리고 있다. 케냐의 전기 버스 회사인 바시고(BasiGo)는 총회 두 번째 세션 저탄소 e-모빌리티 쇼케이스에서 현지 조립된 전기 버스를 선보였다. 바시고는 케냐에서 전기 버스를 내놓은 최초의 회사다. 중국 전기차 제조업체 비야디(BYD)가 설계한 부품을 사용해 현지에서 버스를 조립한다. 모제스 은데리투 바시고 최고매출책임자(CRO)는 케냐의 기후 변화 및 오염과 관련된 문제를 해결하는 것이 시급하다고 말했다. 그는 중국 기업과의 협력이 회사 발전에 많은 도움이 된다고 전했다. [모제스 은데리투 바시고 CRO] "우리는 기후 변화로 인해 세계에서 일어나고 있는 일을 더 이상 묵과할 수 없는 시점에 있습니다. 우리 환경에 무슨 일이 일어나고 있는지 살펴보기 시작해야 할 때입니다. 중국은 전기차 분야의 선두 국가입니다.
Camrelizumab Plus Apatinib and Temozolomide as First-Line Treatment in Patients With Advanced Acral Melanoma
Key Points Question What is the activity of treatment with immune checkpoint inhibitors combined with antiangiogenic agents and chemotherapy in patients with untreated advanced acral melanoma?
ex vivo studies in transmission configuration
1. Introduction Recent scientific advances of polarimetry have expanded its applications from material characterization and metrology,1,2 to biomedical diagnosis,3–10 and made it possible to combine polarimetry with the artificial intelligence algorithms.11–19 However, it is challenging to interpret directly the meaning of the elements of experimental Mueller matrix of biological tissue, especially without the prior knowledge of a physical model accurately describing the measured sample.
Benefit and toxicity of programmed death‐1 blockade vary by ethnicity in patients with advanced melanoma: an international multicentre observational study*
Medical dermatology † Funding sources J.G. and X.B. were supported for their efforts on this work by the National Natural Science Foundation of China (81972562 to J.G.), Beijing Hospitals Authority (QMS20211101 to X.B.) and Beijing Municipal Natural Science Foundation (7214217 to X.B.). ‡ Conflicts of interest Conflicts of interest statements can be found in Appendix 1. § Data availability Deidentified patient data will be made available upon reasonable request when legally and ethically possible.
Probing layered structures by multi-color backscattering polarimetry and machine learning
C. Roa, V. N. D. Le, M. Mahendroo, I. Saytashev, and J. C. Ramella-Roman, “Auto-detection of cervical collagen and elastin in Mueller matrix polarimetry microscopic images using K-NN and semantic segmentation classification,” Biomed. Opt. Express 12(4), 2236–2249 (2021). [Crossref] Y. Dong, J. Wan, L. Si, Y. Meng, Y. Dong, S. Liu, H. He, and H. Ma, “Deriving polarimetry feature parameters to characterize microstructural features in histological sections of breast tissues,” IEEE Trans. Biomed. Eng.
Comparison between image texture and polarization features in histopathology
B. Jones, G. Thomas, J. Sprenger, S. Nofech-Mozes, M. Khorasani, and A. Vitkin, “Peri-tumoural stroma collagen organization of invasive ductal carcinoma assessed by polarized light microscopy differs between OncotypeDX risk group,” J. Biophotonics 13(11), e202000188 (2020). [Crossref] A. Ushenko, Y. Sarkisova, A. Dubolazov, Y. Ushenko, Y. Tomka, A. Karachevtsev, M. Sidor, A. Prydiy, V. Dvorjak, and K.
Randomized Phase II Study of Bevacizumab in Combination With Carboplatin Plus Paclitaxel in Patients With Previously Untreated Advanced Mucosal Melanoma | Journal of Clinical Oncology
PURPOSE Mucosal melanoma (MM) is a highly vascularized tumor with an extremely poor prognosis. In this randomized, open-label, phase II study, we characterized the efficacy and safety of bevacizumab in combination with carboplatin plus paclitaxel (CPB) in patients with previously untreated advanced MM.
Open-label, phase IIa study of dabrafenib plus trametinib in East Asian patients with advanced BRAF V600-mutant cutaneous melanoma
Highlights • Dabrafenib-trametinib was efficacious in East Asians with advanced BRAF V600-mutant cutaneous melanoma. • Efficacy and safety of dabrafenib-trametinib in East Asians was similar to global studies. • No new safety findings were observed with dabrafenib-trametinib in East Asian patients. • Dabrafenib-trametinib could be a treatment option for East Asians with BRAF V600-mutant melanoma.
Axitinib in Combination With Toripalimab, a Humanized Immunoglobulin G4 Monoclonal Antibody Against Programmed Cell Death-1, in Patients With Metastatic Mucosal Melanoma: An Open-Label Phase IB Trial
Mucosal melanoma is a rare melanoma subtype, composing approximately 1.3% of all melanomas in white populations.1 In contrast, it is the second most common subtype in Asian populations, constituting 22% to 25% of all melanomas in Asian patients.2,3 Compared with chronic ultraviolet exposure–associated cutaneous melanoma, mucosal melanoma is a more aggressive malignancy with lower tumor mutational burden (TMB)4 and poorer responses to therapies.5-7 A genome-wide mutational landscape study has...
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