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Luc Van Rompaey on Muck Rack

Luc Van Rompaey

As seen in: Nature
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Articles

Engineering trispecific IL-2 receptor agonistic antibodies through geometry optimization for enhanced Treg targeting

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By Emilie Pollenus, Laurie Rangan, Michelle Stakenborg, Tugsan Tezil, Vanshika Malviya, Gianluca Matteoli, Christophe Blanchetot, Susan Schlenner, Valentina Lykhopiy, Michiel Varheust, Giel Tanghe, Nina Lambrechts, Eva De Langhe, Luc Van Rompaey
| Nature Verified
Abstract Regulatory T cells (Tregs) are central to maintaining immune tolerance, and their selective activation via interleukin-2 (IL-2) signaling presents a promising therapeutic strategy for autoimmune diseases and transplant rejection. Here, we develop IL-2 receptor (IL-2R) agonists, employing trispecific antibodies that simultaneously engage all three IL-2R subunits.
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