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Articles

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS - Nature Medicine

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By Wiebke Möbius, Eckhard Mandelkow, Nicoleta Carmen Cosma, Josef Priller, Andrea Kuhn, Kathrin Brockmann, Daniel Alcolea, Juan Fortea, Alberto Lleó, Ingo Frommann, Lucas Bertram, Michael T. Heneka, Alfredo Ramirez, Alfredo Ramírez, Rudi Beschorner, Randall J. Bateman, Oriol Dols-Icardo, Gunter Hoglinger, Andreas Hermann, Sara Rubio-Guerra, Álvaro Carbayo, Sandra Roeske
| Nature Verified
Abstract Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of 3-repeat (3R) and 4-repeat (4R) tau isoforms.
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