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Lucas Caldi Gomes

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Articles

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target - Nature Communications

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By Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri, Laura Tzeplaeff, Antonia F. Demleitner, Claudia Dufke, Marc Sturm, Tobias B. Haack, Sebastian Streb, Dieter Edbauer, R. Jeroen Pasterkamp, Endre Laczko, Hubert Rehrauer, Christine Carapito, Valentina Bonetto, Stefan Bonn
| Nature Verified
Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanisms underlying ALS.
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Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

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By Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri
| BioRxiv
Abstract Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and lacks effective disease-modifying treatments. Here, we performed a multiomic analysis of the prefrontal cortex of 51 patients with sporadic ALS and 50 control subjects, as well as four transgenic mouse models of C9orf72-, SOD1-, TDP-43-, and FUS-ALS to characterize early and sex-specific disease mechanisms in ALS.
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Metal dyshomeostasis in the substantia nigra of patients with Parkinson's disease or multiple sclerosis

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By Asuncion Carmona, Cnrs France, Lucas Caldi Gomes, Eleonora Carboni
| Wiley Online Library Verified
AD Alzheimer's disease AIFIRA Applications Interdisciplinaires des Faisceaux d'Ions en Région Aquitaine ALS Amyotrophic lateral sclerosis CALR calreticulin CJD Creutzfeldt–Jakob disease DE differential expression DIA-MS data-independent acquisition mass spectrometry FDR false discovery rate FDXR ferredoxin reductase GO gene ontology H&E hematoxylin–eosin HPX hemopexin MRI magnetic resonance imaging MS multiple sclerosis MSA multi-system atrophy NM neuromelanin PCA principal component analysis...
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