Lucas Silva Tortorelli on Muck Rack

Lucas Silva Tortorelli

As seen in: JNeurosci, eLife
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Articles

Locus coeruleus modulation of prefrontal dynamics during attentional switching in mice

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By Marco Nigro, Lucas Silva Tortorelli, Machhindra Garad
| eLife
eLife Assessment This study presents a valuable finding on how the locus coeruleus modulates the involvement of medial prefrontal cortex in set shifting using calcium imaging in mice. The evidence supporting the claims was viewed as solid in revealing the dynamics and potential mechanisms supporting extradimensional shifts. The work is of broad interest to those studying flexible cognition.
Open in Who Shared View Duplicates (3) Issue with article?

Locus coeruleus modulation of single-cell representation and population dynamics in the mouse prefrontal cortex during attentional switching

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By Marco Nigro, Lucas Silva Tortorelli, Machhindra Garad, Natalie E. Zlebnik
| biorxiv.org
Abstract Behavioral flexibility, the ability to adjust behavioral strategies in response to changing environmental contingencies and internal demands, is fundamental to cognitive functions. Despite a large body of pharmacology and lesion studies, the precise neurophysiological mechanisms that underlie behavioral flexibility are still under active investigations. This work is aimed to determine the role of a brainstem-to-prefrontal cortex circuit in flexible rule switching.
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Locus coeruleus modulation of prefrontal dynamics and encoding of flexible rule switching

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By Marco Nigro, Lucas Silva Tortorelli, Kevin Dinh, Machhindra Garad
| biorxiv.org
Abstract Behavioral flexibility, the ability to adjust behavioral strategies in response to changing environmental contingencies and internal demands, is fundamental to cognitive functions. Despite a large body of pharmacology and lesion studies, the underlying neurophysiological correlates and mechanisms that support flexible rule switching are under active investigation.
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