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Designing symmetrical multi-component proteins using a hybrid generative AI approach
Abstract Proteins, the fundamental building blocks of biological function, orchestrate complex cellular processes by assembling into intricate structures through meticulous interactions. The design of specific protein-protein interfaces to create customized protein assemblies holds immense potential for various biotechnological applications. To address the current limitations in designing heteromeric interactions for multi-component assemblies, we developed a hybrid generative AI design approach.
Assessment of oligomerization of bacterial micro-compartment shell components with the tripartite GFP reporter technology
Loading metrics Open Access Peer-reviewed Research Article Citation: Barthe L, Soldan V, Garcia-Alles LF (2023) Assessment of oligomerization of bacterial micro-compartment shell components with the tripartite GFP reporter technology. PLoS ONE 18(11): e0294760. https://doi.org/10.1371/journal.pone.0294760 Editor: Maria Gasset, Consejo Superior de Investigaciones Cientificas, SPAIN Received: September 10, 2023; Accepted: November 8, 2023; Published: November 27, 2023 Copyright: © 2023 Barthe et al.
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