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Articles

Microtubule polymerization generates microtentacles important in circulating tumor cell invasion

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By Reza Shaebani, Ludger Santen, Lucina Kainka, Jonas Bosche
| buff.ly
Significance Microtentacles are microtubule-based membrane protrusions that promote adhesion and extravasation of circulating tumor cells from the bloodstream. Here, we provide the first evidence that microtentacle formation is driven by the polymerization of microtubules against the cell membrane and not by microtubule sliding driven by molecular motors.
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