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Lucy A. Bartho on Muck Rack

Lucy A. Bartho

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Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta

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By Siddharth Acharya, Eric Hanssen, Veronica B. Botha, Tia Smith, Zlatan Trifunovic, John E. Schjenken, Anthony Perkins, Joanna L James, Kirsty G Pringle, James Bouwer, Roger Smith, Joshua Fisher, Sahan Jayatissa, Lucy A. Bartho
| Nature Verified
Abstract Mitochondria adapt their structure through fusion and fission, yet how their morphology and cristae architecture change as cells differentiate remains unclear. The human placenta is a valuable model for studying mitochondrial diversity within a single tissue. As epithelial trophoblast cells of the placenta differentiate, their accompanying mitochondria morphologically and functionally transform. We use array tomography to characterise mitochondrial volume and network complexity.
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