Lucy Mary Perrem

ABSTRACT Introduction Pulmonary exacerbations are common events in children with cystic fibrosis (CF) and are usually treated with oral antibiotics on an outpatient basis. Even these mild clinical events are clinically meaningful and contribute to the progression of lung disease. Areas covered This review discusses the challenges in diagnosing pulmonary exacerbations in children in the absence of a standardized definition.

Twitter @luperr84 Contributors LP contributed to conceptualisation of the study design, data collection, data analysis, data interpretation, figures and wrote the manuscript. SS contributed to conceptualisation and design of the study, funding acquisition, data analysis, data interpretation, figures and manuscript review and editing; SDD contributed to funding acquisition, study design, data interpretation and manuscript review and editing.

Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls http://orcid.org/0000-0003-4970-8889Lucy Perrem1,2,3,4,5, Sanja Stanojevic6,7, Melinda Solomon1,4,5, http://orcid.org/0000-0003-0331-9642Hartmut Grasemann1,4,5, Neil Sweezey1,4,5, Valerie Waters4,5,8, Don B Sanders9, Stephanie D Davis10, http://orcid.org/0000-0003-4057-6592Felix Ratjen1,4,5 1Division of Respiratory Medicine, The Hospital for Sick Children, Toronto,...