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Dendrites endow neurons with multiple compartments within their elaborate morphologies. In a recent study published in the journal Science,used elegant techniques to show that augmenting the intracellular calcium released by the endoplasmic reticulum caused behaviorally relevant plasticity to occur in spatially distinct dendritic compartments.
Research ArticleResearch Article: New Research, Neuronal Excitability eNeuro 9 (3) ENEURO.0060-22.2022; DOI: https://doi.org/10.1523/ENEURO.0060-22.2022 Abstract The dendrites of cortical pyramidal neurons receive synaptic inputs from different pathways that are organized according to their laminar target. This architectural scheme provides cortical neurons with a spatial mechanism to separate information, which may support neural flexibility required during learning.
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