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Abstract Numerous studies of hippocampal synaptic function in learning and memory have established the functional significance of the scaffolding A-kinase anchoring protein 150 (AKAP150) in kinase and phosphatase regulation of synaptic receptor and ion channel trafficking/function and hence synaptic transmission/plasticity and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a critical role in brain′s processing of rewarding/aversive experiences.
Abstract : Irritable bowel syndrome (IBS), a multifactorial intestinal disorder, is often associated with a disruption in intestinal permeability as well as an increased expression of pro-inflammatory markers.
Journal of NeurotraumaAhead of Print Original ArticleOpen AccessCreative Commons license Abstract Affective disorders including depression (characterized by reduced motivation, social withdrawal, and anhedonia), anxiety, and irritability are frequently reported as long-term consequences of mild traumatic brain injury (mTBI) in addition to cognitive deficits, suggesting a possible dysregulation within mood/motivational neural circuits.
Stress hormones, such as CRF (also known as CRH), inhibit the “reward” signals provided by dopamine signaling in the brain after or in anticipation of a given action. Potentially because of this, severe or chronic stress is associated with depression and can impair decision-making, and early-childhood stress is linked to long-term mental health problems and behavioral disorders. Authement et al.
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